个人简介
唐鑫,博士,金沙威尼斯欢乐娱人城副研究员、硕士研究生导师,主要从事食品微生物功能发掘与利用相关研究,重点围绕食品微生物转化功能性代谢产物及其应用展开,研究方向包括食品微生物资源挖掘与应用、功能活性物质的合成途径及调控机制、食品微生物发酵活性物质的研究及产品开发、功能性食品和日化原料的研究与开发等。近年来主持或参与国家自然科学基金、国家重点研发计划、江苏省自然科学基金、中国博士后基金、江苏省博士后基金、金沙威尼斯欢乐娱人城自主科研计划、金沙威尼斯欢乐娱人城食品科学与技术国家重点实验室前沿交叉研究项目、企业横向项目等20余项,成果获教育部高等学校科学技术进步奖二等奖和中国商业联合会科学技术奖二等奖;以第一或者通讯作者在Trends in Food Science & Technology, Critical Reviews in Food Science and Nutrition, Journal of Agricultural and Food Chemistry,Food Chemistry,Food & Function,Antioxidants,Frontiers in Microbiology, Fungal Genetics and Biology, Process Biochemistry,微生物学报,食品与发酵工业,中国油脂等国内外主流学术期刊上发表论文30余篇;以主要发明人申请国际或国家发明专利50余项,获得授权专利20余项;参与专著《Lactic Acid Bacteria: Omics and Functional Evaluation》(Springer出版社)、《Lactic Acid Bacteria in Foodborne Hazards Reduction: Physiology to Practice》(Springer出版社)、《High Value Processing Technologies》(Nova Science出版社)、《乳酸菌科学与技术》(科学出版社)的编写工作。
学习工作经历:
2019.05-至 今,金沙威尼斯欢乐娱人城,金沙威尼斯欢乐娱人城,副研究员
2016.01-2019.05,金沙威尼斯欢乐娱人城,金沙威尼斯欢乐娱人城,助理研究员(校聘副研究员)
2010.09-2016.01,金沙威尼斯欢乐娱人城,食品科学与工程,硕博连读
2006.09-2010.06,金沙威尼斯欢乐娱人城,食品科学与工程,本科
研究方向:
产功能性代谢物的微生物资源挖掘与应用
食品微生物合成/转化功能性成分的途径解析
微生物合成/转化功能性物质的调控机制
食品微生物发酵植化物(药食同源/果蔬/中草药)的研究
功能食品(发酵制品/后生元/合生制剂)的研究与开发
日化原料(口服/外用美容)的创制与开发
主要承担项目:
[1]国家自然科学青年基金项目:异柠檬酸脱氢酶在高山被孢霉脂质合成中的作用和调控机制(31901659),2020.01-2022.12,25万元,主持
[2]江苏省自然科学青年基金项目:异柠檬酸脱氢酶对产油丝状真菌脂质积累的调控及其分子机制(BK20160172),2016.07-2019.06,20万元,主持
[3]中国博士后基金面上项目:高山被孢霉脂质积累的碳代谢流分析及关键基因改造(2017M611701),2017.02-2018.11,5万元,主持
[4]江苏省博士后科研资助计划:产油真菌高山被孢霉的脂质合成调控机制(1701061C),2017.06-2018.11,2万元,主持
[5]金沙威尼斯欢乐娱人城食品科学与技术国家重点实验室前沿交叉研究项目:具有改善消化不良症状的食品功能因子挖掘,2021.01-2021.12,20万元,主持
[6]金沙威尼斯欢乐娱人城自主科研计划青年基金:高山被孢霉的代谢流分析及关键基因调控研究(JUSRP11736),2017.01-2018.12,8万元,主持
[7]国家重点研发计划课题:油脂的营养、健康功能与代谢机制(2017YFD0400202),2017.07-2021.06,365万元,参与
[8]企业横向项目:富锌益生菌的发酵与富集工艺优化及功能研究,2018-2019,50万元,主持
[9]企业横向项目:高产纳豆激酶与降嘌呤菌株的筛选及复合发酵技术研究,2020-2022,40万元,主持
[10]企业横向项目:具有抗氧化作用益生菌的筛选及外用护肤功效研究,2019-2021,70万元,主持
[11]企业横向项目:美容食品联合创新研发,2021-2021,64.73万元,主持
[12]企业横向项目:中草药护肤多糖发酵产业化项目, 2021-2023,298万,参与
代表性论文:
[1]Wang Bulei,Tang Xin*, Mao Bingyong, Zhang Qiuxiang, Tian Fengwei, Zhao Jianxin, Chen Wei, Cui Shumao. Effects of in vitro fecal fermentation on the metabolism and antioxidant properties of cyanidin-3-O-glucoside.Food Chemistry, 2024, 431, 137132.(IF: 8.8,通讯作者)
[2] Zhang Shuling, Mao Bingyong, Cui Shumao, Zhang Qiuxiang, Zhao Jianxin,Tang Xin*, Chen Wei. Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate.Critical Reviews in Food Science and Nutrition, 2023, DOI: 10.1080/10408398.2023.2170972.(IF: 10.2,通讯作者)
[3]Zhang Mengwei, Cui Shumao, Mao Bingyong, Zhang Qiuxiang, Zhao Jianxin,Tang Xin*, Chen Wei. Urolithin A Produced by Novel Microbial Fermentation Possesses Anti-aging Effects by Improving Mitophagy and Reducing Reactive Oxygen Species in Caenorhabditis elegans.Journal of Agricultural and Food Chemistry, 2023, 71, 6348-6357.(IF: 6.1,通讯作者)
[4]Zhang Mingjun, Cui Shumao, Mao Bingyong, Zhang Qiuxiang, Zhao Jianxin,Tang Xin*, Chen Wei. Effects and mechanism of gastrodin supplementation on exercise-induced fatigue in mice.Food & Function, 2023, 14, 787.(IF: 6.1,通讯作者)
[5]Tang Xin﹟, Ling Fengzhu﹟, Zhao Jianxin, Chen Haiqin*, Chen Wei. Overexpression of Citrate-Malate Carrier Promoted Lipid Accumulation in Oleaginous Filamentous Fungus Mortierella alpina.Journal of Agricultural and Food Chemistry, 2023, 71, 7468-7476.(IF: 6.1,第一作者)
[6]Tang Xin, Wang Bulei, Mao Binyong, Zhao Jianxin, Liu Guangrong, Yang Kaiye*, Cui Shumao*. Screening of Microbial Strains Used to Ferment Dendrobium officinale to Produce Polysaccharides, and Investigation of These Polysaccharides’ Skin Care Effects.Processes, 2023, 11, 2563.(IF: 3.5,第一作者)
[7]Zhang Mengwei﹟, Cui Shumao﹟, Mao Bingyong, Zhang Qiuxiang, Zhao Jianxin, Zhang Hao,Tang Xin*, Chen Wei. Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation.Critical Reviews in Food Science and Nutrition, 2022, DOI: 10.1080/10408398.2022.2036693.(IF: 10.2,通讯作者)
[8]Wang Bulei, Cui Shumao, Mao Bingyong, Zhang Qiuxiang, Tian Fengwei, Zhao Jianxin,Tang Xin*, Chen Wei. Cyanidin Alleviated CCl(4)-Induced Acute Liver Injury by Regulating the Nrf2 and NF-κB Signaling Pathways.Antioxidants, 2022, 11(12), 2383.(IF: 7.0,通讯作者)
[9]Wang Xuxu,Tang Xin*, Chen Haiqin, Zhang Hao, Chen Yong Q., Zhao Jianxin, Chen Wei. Purification and characterization of isocitrate dehydrogenase from Mortierella alpina.Process Biochemistry, 2022, 121, 575-583.(IF: 4.4,通讯作者)
[10]Xiang Qunran, Guo Weiling,Tang Xin*, Cui Shumao, Zhang Feng, Liu Xiaoming, Zhao Jianxin, Zhang Hao, Mao Bingyong*, Chen Wei. Capsaicin-the spicy ingredient of chili peppers: A review of the gastrointestinal effects and mechanisms.Trends in Food Science & Technology, 2021, 116: 755-765. (IF: 15.3,通讯作者)
[11]Tang Xin, Sun Xiaoqi, Wang Xuxu, Zhang Hao, Chen Yong Q., Zhao Jianxin, Chen Haiqin*, Chen Wei. Characterization of NAD+/NADP+-specific isocitrate dehydrogenases from oleaginous fungus Mortierella alpina involved in lipid accumulation.Frontiers in Nutrition, 2021, 8: 746342. (IF: 5.0,第一作者)
[12]Tang Xin﹟, Chang Lulu﹟, Gu Shujie, Zhang Hao, Chen Yong Q., Chen Haiqin*, Zhao Jianxin*, Chen Wei, Role of beta-isopropylmalate dehydrogenase in lipid biosynthesis of the oleaginous fungus Mortierella alpina.Fungal Genetics and Biology, 2021, 152: 103572. (IF: 3.0,第一作者)
[13] Ling Fengzhu,Tang Xin*, Zhang Hao, Chen Yong Q., Zhao Jianxin, Chen Haiqin, Chen Wei, 2021. Role of the mitochondrial citrate-oxoglutarate carrier in lipid accumulation in the oleaginous fungus Mortierella alpina.Biotechnology Letters, 2021, 43: 1455-1466. (IF: 2.7,通讯作者)
[14]Tang Xin, Chen Haiqin, Gu Zhennan, Zhang Hao, Chen Yong Q., Song Yuanda*, Chen Wei*. Role of g6pdh and leuB on lipid accumulation in Mucor circinelloides.Journal of Agricultural and Food Chemistry, 2020, 68:4245-4251. (IF: 6.1,第一作者)
[15] Chang Lulu,Tang Xin*, Lu Hengqian, Zhang Hao, Chen Yong Q., Chen Haiqin*, Chen Wei. Role of adenosine monophosphate deaminase during fatty acid accumulation in oleaginous fungus Mortierella alpina.Journal of Agricultural and Food Chemistry, 2019, 67: 9551-9559. (IF: 6.1,通讯作者)
[16]Tang Xin, Chen Haiqin*, Mei Tiantian, Ge Chengfeng, Gu Zhennan, Zhang Hao, Chen Yong Q., Chen Wei. Characterization of an omega-3 desaturase from Phytophthora parasitica and application for eicosapentaenoic acid production in Mortierella alpina.Frontiers in Microbiology, 2018, 9: 1878. (IF: 5.2,第一作者)
[17]Tang Xin, Chen Haiqin*, Gu Zhennan, Zhang Hao, Chen Yong Q., Song Yuanda*, Chen Wei, Comparative proteome analysis between high lipid-producing strain Mucor circinelloides WJ11 and low lipid-producing strain CBS 277.49 ,Journal of Agricultural and Food Chemistry, 2017, 65: 5074-5082. (IF: 6.1,第一作者)
[18]唐鑫,蔡美君,崔树茂,毛丙永,赵建新,刘光荣,杨凯业*.发酵天山雪莲粗多糖的菌株筛选及护肤功效研究.微生物学报, 2023, 63, 1551-1565.(中文核心,第一作者)
[19]王旭旭,孙晓琪,陈海琴,赵建新,陈卫,唐鑫*.高山被孢霉NADP+依赖型异柠檬酸脱氢酶的异源表达与活性分析.食品与发酵工业, 2023,49, 13-19.(中文核心,通讯作者)
[20]唐鑫,顾舒婕,常璐璐,王旭旭,赵建新,张灏,陈海琴*,陈卫.高山被孢霉产孢培养基的筛选.中国油脂,2021, 46, 123-127.(中文核心,第一作者)
[1]教育部高等学校科学技术进步奖二等奖,2019,排名7/11.
[2]中国商业联合会科学技术奖二等奖,2018,排名,6/10.
[3]金沙威尼斯欢乐娱人城第十届青年教师教学竞赛一等奖,2022.
[4]金沙威尼斯欢乐娱人城第九届青年教师教学竞赛二等奖,2021.
代表性专利(授权):
[1] Chen Haiqin, Chen Yongquan, Chen Wei, Ge Chengfeng,Tang Xin, Gu Zhennan, Zhang Hao. Preparation of Mortierella alpina CCFM698 thalli and application thereof in feed additive. 2022.3,美国, US 11266167 B2.
[2]唐鑫,毛丙永,崔树茂,邬佳颖,张秋香,赵建新,陈卫.一株高转化萝卜硫苷且产萝卜硫素的副干酪乳杆菌CCFM1221. 2023.8,中国, ZL 202210405998.8.
[3]唐鑫,陈海琴,凌凤珠,赵建新,张灏,陈永泉,陈卫.一种柠檬酸转运蛋白及其在脂质合成中的应用, 2022.4,中国, ZL 202110079150.6.
[4]唐鑫,陈海琴,常璐璐,顾舒婕,赵建新,张灏,陈永泉,陈卫.一种β-异丙基苹果酸脱氢酶及其在脂质合成中的应用. 2020.12,中国, ZL 201910777811.5.
[5]崔树茂,唐鑫,毛丙永,赵建新.提高中药多糖得率并调节皮肤屏障及免疫的枯草芽孢杆菌. 2023.8,中国, ZL 202110963096.1.
[6]崔树茂,唐鑫,毛丙永,孙媛媛,赵建新.一种通过发酵控制提高罗伊氏乳杆菌冻干存活率的方法. 2023.6,中国, ZL 202110583243.2.
[7]崔树茂,唐鑫,毛丙永,赵建新.一株可发酵石斛且其发酵液可有效修复日光皮炎的罗伊氏乳杆菌, 2023.4,中国, ZL 202110962880.0.
[8]崔树茂,唐鑫,孙媭,毛丙永,杨波,陆文伟,赵建新.一株具有缓解HaCaT细胞氧化损伤作用的动物双歧杆菌. 2022.8,中国, ZL 202110457002.3.
[9]陈海琴,唐鑫,陈卫,黄明旺,赵建新,张灏,陈永泉.一种基于溶氧与pH调控高山被孢霉产EPA的发酵方法, 2021.9,中国, ZL 201910205750.5.
[10]陈海琴,唐鑫,常璐璐,赵建新,张灏,陈卫.一种蔗糖非发酵型蛋白激酶调节亚基及其应用. 2021.5,中国, ZL 201910870749.4.
代表性专利(申请):
[1]唐鑫,张孟炜,毛丙永,张秋香,刘小鸣,崔树茂,赵建新,陈卫.一株可产尿石素A抗衰老的植物乳杆菌及其应用. 2022.11,中国, CN 202211404309.8.
[2]唐鑫,郑雪丽,毛丙永,张秋香,王刚,崔树茂,赵建新,陈卫.植物乳植杆菌CCFM1295制备的具有上调皮肤细胞HA合成酶表达的后生元. 2023.1,中国, CN 202310065917.9.
[3]唐鑫,毛丙永,张秋香,崔树茂,杨波,赵建新,陈卫.一株促进葛根素功效发挥的肠膜明串珠菌肠膜亚种及其应用. 2022.11,中国, CN 202211444507.7.
[4]唐鑫,郭伟灵,毛丙永,崔树茂,张秋香,赵建新,张灏,陈卫.一株高效表达腺苷脱氨酶缓解结肠炎副干酪乳杆菌. 2022.5,中国, CN 202210575758.2.
[5]唐鑫,崔树茂,韩欣然,张秋香,毛丙永,赵建新.一株高富集有机锌的发酵乳杆菌. 2022.2,中国, CN 202210124428.1.
[6]张秋香,唐鑫,郑雪丽,毛丙永,陆文伟,崔树茂,赵建新.一株植物乳植杆菌CCFM1297制备的上调皮肤细胞HA前体酶表达的后生元. 2023.1,中国, CN 202310066059.X.
[7]崔树茂,唐鑫,毛丙永,张秋香,陆文伟,赵建新,陈卫.一株通过代谢葛根素提升其功效的两歧双歧杆菌及其应用. 2022.11,中国, CN 202211444502.4.
[8]崔树茂,唐鑫,张孟炜,毛丙永,张秋香,杨波,赵建新,陈卫.一株植物乳杆菌及其在产生尿石素A中的应用. 2022.11,中国, CN 202211409720.4.
[9]崔树茂,唐鑫,刘飞,毛丙永,张秋香,赵建新.一株既能转化甘草酸又能转化芦丁和大豆苷的植物乳植杆菌CCFM1275. 2023.8,中国, CN202311073347.4.
[10]毛丙永,唐鑫,张秋香,崔树茂,翟齐啸,赵建新,陈卫.一株能够转化葛根素并显著提高其缓解肝细胞损伤的青春双歧杆菌及其应用. 2022.11,中国, CN202211444509.6.
[1]《现代食品生物技术》
[2]《微生物学实验》